What is the correct response to significant extravasation of sodium tetradecyl sulfate (STS) to the subcutaneous tissue?

The correct response to significant extravasation of sodium tetradecyl sulfate (STS) to the subcutaneous tissue is the injection of hyaluronidase. Hyaluronidase is an enzyme that breaks down hyaluronic acid in the extracellular matrix, which can help facilitate the absorption of the extravasated solution. This action serves to mitigate potential tissue damage and helps the body to clear the extravasated substance more effectively.

When STS leaks into the subcutaneous tissue, it can cause local irritation and necrosis due to its sclerosing properties. Administering hyaluronidase can help reduce the localized inflammatory response and minimize complications. Additionally, hyaluronidase promotes better distribution of fluids in the area, aiding in the resolution of the extravasation.

In contrast, while some may consider compression of the area, the primary goal in this scenario is to address the local response to the irritant, which is best done through the enzymatic breakdown provided by hyaluronidase. Referral to a specialist may be necessary in severe cases but would not be the immediate response to extravasation. Injection of saline may lead to further complications, as it does not address the underlying problem of STS in the tissue.