Which area of circulation is most commonly associated with PTS?

Post-thrombotic syndrome (PTS) is a condition that can occur after a deep vein thrombosis (DVT), primarily affecting areas where the veins are typically larger and where the flow dynamics can be significantly disturbed by the presence of obstructive lesions. The iliofemoral circulation is the area most associated with PTS because this region includes major veins—namely the common femoral vein and the external iliac vein—which are critical for normal blood return from the lower extremities to the heart.

When a DVT occurs in the iliofemoral region, its potential to obstruct venous outflow is more pronounced due to the size and the functional importance of these veins in draining blood from the legs. The complications arising from venous stasis, increased venous pressure, and consequent valvular incompetence culminate in the symptoms that characterize post-thrombotic syndrome, such as swelling, pain, and skin changes.

While superficial circulation and popliteal circulation are also parts of the venous system that can experience thrombosis, they are less commonly associated with PTS due to the nature of their anatomical and functional characteristics. The inferior vena cava circulation, while significant, serves as a tributary system and is not the