Which inherited thrombophilia is associated with an 80-fold increase in the risk of VTE?

Factor V Leiden is a genetic mutation that results in a version of the factor V protein that is resistant to the inactivation by activated protein C. This means that the coagulation cascade remains activated longer than it should, leading to an increased tendency for thrombosis. The resistance conferred by the mutation is significant; it has been documented to increase the risk of venous thromboembolism (VTE) by as much as 80-fold in those who are homozygous for the mutation compared to individuals without this mutation.

The association with such a high risk for VTE specifically highlights the importance of recognizing and managing this condition in patients with a family history or other risk factors for thrombosis. Being vigilant for symptoms of VTE in individuals with Factor V Leiden can greatly influence management and preventative strategies for those affected.